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The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

descriptionPublicationkeyboard_double_arrow_right Article 07 Jan 1994 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 263, pages 98-101 (issn: 0036-8075, eissn: 1095-9203,

Authors: James H. Resau; Ilan Tsarfaty; Pedro Pinto da Silva; Shen Rulong; George F. Vande Woude; Sing Rong;

doi: 10.1126/science.7505952

pmid: 7505952

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

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Abstract

Coexpression of the human Met receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in NIH 3T3 fibroblasts causes the cells to become tumorigenic in nude mice. The resultant tumors display lumen-like morphology, contain carcinoma-like focal areas with intercellular junctions resembling desmosomes, and coexpress epithelial (cytokeratin) and mesenchymal (vimentin) cytoskeletal markers. The tumor cells also display enhanced expression of desmosomal and tight-junction proteins. The apparent mesenchymal to epithelial conversion of the tumor cells mimics the conversion that occurs during embryonic kidney development, suggesting that Met-HGF/SF signaling plays a role in this process as well as in tumors that express both epithelial and mesenchymal markers.

Keywords

Hepatocyte Growth Factor, Mice, Nude, Receptor Protein-Tyrosine Kinases, Epithelial Cells, 3T3 Cells, Desmosomes, Neoplasms, Experimental, Proto-Oncogene Proteins c-met, Kidney, Transfection, Proto-Oncogene Mas, Mesoderm, Mice, Cell Transformation, Neoplastic, Proto-Oncogene Proteins, Proto-Oncogenes, Animals, Keratins, Vimentin, Signal Transduction

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The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

2 Research products, page 1 of 1

Detection of hepatocyte growth factor/scatter factor receptor (c-Met) and MUC1 from the axillary fluid drainage in patients after breast cancer surgery.

Met-HGF/SF: tumorigenesis, invasion and metastasis.