Type 1 metabotropic glutamate receptors (m G lu1) trigger the gating of G lu D 2 delta glutamate receptors
Copyright policy )Type 1 metabotropic glutamate receptors (m G lu1) trigger the gating of G lu D 2 delta glutamate receptors
The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.
- Inserm France
- Institut des Sciences Biologiques France
- Sorbonne Paris Cité France
- University of Paris France
- French National Centre for Scientific Research France
Male, [SCCO.NEUR] Cognitive science/Neuroscience, Glycine, Excitatory Postsynaptic Potentials, Resorcinols, Receptors, Metabotropic Glutamate, Mice, Inbred C57BL, Purkinje Fibers, Mice, HEK293 Cells, Receptors, Glutamate, Cerebellum, Excitatory Amino Acid Agonists, Animals, Humans, Calcium Signaling, Ion Channel Gating
Male, [SCCO.NEUR] Cognitive science/Neuroscience, Glycine, Excitatory Postsynaptic Potentials, Resorcinols, Receptors, Metabotropic Glutamate, Mice, Inbred C57BL, Purkinje Fibers, Mice, HEK293 Cells, Receptors, Glutamate, Cerebellum, Excitatory Amino Acid Agonists, Animals, Humans, Calcium Signaling, Ion Channel Gating
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