Overexpression of <i>KLF13</i> and <i>FGFR3</i> in Oral Cancer Cells
Copyright policy )Overexpression of <i>KLF13</i> and <i>FGFR3</i> in Oral Cancer Cells
KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.
- University of Pittsburgh United States
Adult, Aged, 80 and over, Male, Cell Cycle, Kruppel-Like Transcription Factors, Cell Cycle Proteins, Cell Differentiation, Middle Aged, Gene Expression Regulation, Neoplastic, Repressor Proteins, Cell Line, Tumor, Radiation, Ionizing, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Receptor, Fibroblast Growth Factor, Type 3, Female, Mouth Neoplasms, Cell Division, Neoplasm Staging
Adult, Aged, 80 and over, Male, Cell Cycle, Kruppel-Like Transcription Factors, Cell Cycle Proteins, Cell Differentiation, Middle Aged, Gene Expression Regulation, Neoplastic, Repressor Proteins, Cell Line, Tumor, Radiation, Ionizing, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Receptor, Fibroblast Growth Factor, Type 3, Female, Mouth Neoplasms, Cell Division, Neoplasm Staging
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