Measles Viruses Possessing the Polymerase Protein Genes of the Edmonston Vaccine Strain Exhibit Attenuated Gene Expression and Growth in Cultured Cells and SLAM Knock-In Mice
Copyright policy )Measles Viruses Possessing the Polymerase Protein Genes of the Edmonston Vaccine Strain Exhibit Attenuated Gene Expression and Growth in Cultured Cells and SLAM Knock-In Mice
ABSTRACT Live attenuated vaccines against measles have been developed through adaptation of clinical isolates of measles virus (MV) in various cultured cells. Analyses using recombinant MVs with chimeric genomes between wild-type and Edmonston vaccine strains indicated that viruses possessing the polymerase protein genes of the Edmonston strain exhibited attenuated viral gene expression and growth in cultured cells as well as in mice expressing an MV receptor, signaling lymphocyte activation molecule, regardless of whether the virus genome had the wild-type or vaccine-type promoter sequence. These data demonstrate that the polymerase protein genes of the Edmonston strain contribute to its attenuated phenotype.
- National Presto Industries United States
- University of Tokyo Japan
- Japan Science and Technology Agency Japan
- Kyushu University Japan
Vaccines, Synthetic, Green Fluorescent Proteins, Measles Vaccine, Receptors, Cell Surface, RNA-Dependent RNA Polymerase, Vaccines, Attenuated, Mice, Signaling Lymphocytic Activation Molecule Family Member 1, Antigens, CD, Measles virus, Chlorocebus aethiops, Animals, RNA, Viral, Vero Cells
Vaccines, Synthetic, Green Fluorescent Proteins, Measles Vaccine, Receptors, Cell Surface, RNA-Dependent RNA Polymerase, Vaccines, Attenuated, Mice, Signaling Lymphocytic Activation Molecule Family Member 1, Antigens, CD, Measles virus, Chlorocebus aethiops, Animals, RNA, Viral, Vero Cells
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