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Science Signaling
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Science Signaling
Article . 2019 . Peer-reviewed
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Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

Authors: Fox, Jamie C.; Thomas, Monica A.; Dishman, Acacia F.; Larsen, Olav; Nakayama, Takashi; Yoshie, Osamu; Rosenkilde, Mette Marie; +1 Authors

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

Abstract

Key amino acids in the chemokine XCL1 mediate its specificity for and activation of its receptor XCR1.

Keywords

3101 Biochemistry and cell biology, Protein Conformation, Molecular Dynamics Simulation, 0601 Biochemistry and Cell Biology, Chemokines, C, Receptors, G-Protein-Coupled, Radioligand Assay, Structure-Activity Relationship, HEK293 Cells, COS Cells, Chlorocebus aethiops, Animals, Humans, Amino Acids, Chemokines, Protein Binding, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Top 10%
Green
bronze