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https://dx.doi.org/10.1038/s41...
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DNA methylation status correlates with adult β-cell regeneration capacity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 12 Feb 2021 English Publisher:Springer Science and Business Media LLCJournal:npj Regenerative Medicine, volume 6 (eissn: 2057-3995, Copyright policy )Funded by:ANR | SIGNALIFE, ANR | BromoBeta, NHMRC | Identifying the epigenomi...
Authors: Ishant Khurana; Keith Al-Hasani; Scott Maxwell; Harikrishnan K.N.; Jun Okabe; Mark E. Cooper; Patrick Collombat; +1 Authors

doi: 10.1038/s41536-021-00119-1

pmid: 33580013

pmc: PMC7881134

handle: 11343/272983

DNA methylation status correlates with adult β-cell regeneration capacity

Abstract

AbstractThe role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

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Keywords

R, 610, Medicine, Brief Communication, 576

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Top 10%
Green
gold
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