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Gene Expression Patterns
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Gene Expression Patterns
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Gene Expression Patterns
Article . 2012
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Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti

Authors: Carlisle, Francesca A.; Steel, Karen; Lewis, Morag A.;

Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti

Abstract

The development of the organ of Corti and the highly specialized cells required for hearing involves a multitude of genes, many of which remain unknown. Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and early postnatal. Kcna10, a tetrameric Shaker-like potassium channel, is expressed strongly in the hair cells themselves. Odf2, as its centriolar isoform Cenexin, marks the dendrites extending to and contacting hair cells, and Pxn, a focal adhesion scaffold protein, is most strongly expressed in pillar cells during the ages studied. The roles of these genes are yet to be elucidated, but their specific expression patterns imply potential functional significance in the inner ear.

Keywords

Mice, Knockout, 570, Gene Expression Profiling, 610, Kcna10, Article, Mice, Inbred C57BL, Cenexin, Cellular and Molecular Neuroscience, Mice, Developmental Neuroscience, Hearing, Inner ear, Genetics, Shaker Superfamily of Potassium Channels, Animals, Pxn, Paxillin, Odf2, Molecular Biology, Organ of Corti, Heat-Shock Proteins

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Average
Green
hybrid