Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
The development of the organ of Corti and the highly specialized cells required for hearing involves a multitude of genes, many of which remain unknown. Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and early postnatal. Kcna10, a tetrameric Shaker-like potassium channel, is expressed strongly in the hair cells themselves. Odf2, as its centriolar isoform Cenexin, marks the dendrites extending to and contacting hair cells, and Pxn, a focal adhesion scaffold protein, is most strongly expressed in pillar cells during the ages studied. The roles of these genes are yet to be elucidated, but their specific expression patterns imply potential functional significance in the inner ear.
- Wellcome Trust United Kingdom
- Wellcome Trust Sanger Institute Wellcome Trust Genome Campus United Kingdom
- King's College London United Kingdom
- Wellcome Sanger Institute United Kingdom
- Kings College London, University of London United Kingdom
Mice, Knockout, 570, Gene Expression Profiling, 610, Kcna10, Article, Mice, Inbred C57BL, Cenexin, Cellular and Molecular Neuroscience, Mice, Developmental Neuroscience, Hearing, Inner ear, Genetics, Shaker Superfamily of Potassium Channels, Animals, Pxn, Paxillin, Odf2, Molecular Biology, Organ of Corti, Heat-Shock Proteins
Mice, Knockout, 570, Gene Expression Profiling, 610, Kcna10, Article, Mice, Inbred C57BL, Cenexin, Cellular and Molecular Neuroscience, Mice, Developmental Neuroscience, Hearing, Inner ear, Genetics, Shaker Superfamily of Potassium Channels, Animals, Pxn, Paxillin, Odf2, Molecular Biology, Organ of Corti, Heat-Shock Proteins
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