Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity
Copyright policy )Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity
Mouse PTP-BL is a large, nontransmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains, and a COOH-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis, and neurite outgrowth. To investigate the biological function of PTP-BL enzyme activity, we have generated mice that lack the PTP-BL PTP moiety. These PTP-BLΔP/ΔPmice are viable and fertile and do not present overt morphological alterations. Although PTP-BL is expressed in most hematopoietic cell lineages, no alterations of thymocyte development in PTP-BLΔP/ΔPmice could be detected. Sciatic nerve lesioning revealed that sensory nerve recovery is unaltered in these mice. In contrast, a very mild but significant impairment of motor nerve repair was observed. Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule.
- Radboud University Nijmegen Netherlands
- Radboud University Nijmegen Medical Centre Netherlands
Male, Motor Neurons, Nerve Crush, Body Weight, Protein Tyrosine Phosphatase, Non-Receptor Type 13, Sciatic Nerve, Axons, Nerve Regeneration, Mice, Protein Transport, Phenotype, UMCN 5.3: Cellular energy metabolism, Animals, Female, Lymphocytes, Neurons, Afferent, RNA, Messenger, UMCN 1.4: Immunotherapy, gene therapy and transplantation, Protein Tyrosine Phosphatases, Alleles, Sequence Deletion
Male, Motor Neurons, Nerve Crush, Body Weight, Protein Tyrosine Phosphatase, Non-Receptor Type 13, Sciatic Nerve, Axons, Nerve Regeneration, Mice, Protein Transport, Phenotype, UMCN 5.3: Cellular energy metabolism, Animals, Female, Lymphocytes, Neurons, Afferent, RNA, Messenger, UMCN 1.4: Immunotherapy, gene therapy and transplantation, Protein Tyrosine Phosphatases, Alleles, Sequence Deletion
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!