An Approach to the Simultaneous Determination of a Panel of Five Biomarkers for the Early Detection of Brain Cancer Using the Stochastic Method
Copyright policy )An Approach to the Simultaneous Determination of a Panel of Five Biomarkers for the Early Detection of Brain Cancer Using the Stochastic Method
The simultaneous determination of heregulin-α and HER 1–4 plays an important role in brain cancer diagnosis and treatment. To date, only enzyme-linked immunosorbent assay (ELISA) or a semiquantitative colorimetric method have been used for the assay of these biomarkers; these methods are quite expensive and can only determine one biomarker in a run. Four 3D stochastic microsensors based on multi-walled carbon nanotubes enriched with gold nanoparticles and modified with inulin were designed for the simultaneous determination of heregulin-α and HER 1–4 in tumor brain tissue and whole blood samples. For the simultaneous measurement of HRG-α and HER 1–4, all sensors demonstrated low limits of determination (as fg mL−1 magnitude order), high sensitivities, and wide concentration ranges. From biological samples, high recovery values of more than 96% of analytes were obtained. The proposed sensor can detect HER 1–4 and heregulin-α in whole blood and tumor tissue samples at the same time.
Chemistry, 3D stochastic microsensors, inulin, HRG-α, gold nanoparticles, HER-1, 3D stochastic microsensors; multi-walled carbon nanotubes; gold nanoparticles; inulin; HRG-α; HER-1; HER-2; HER-3; HER-4; brain cancer, multi-walled carbon nanotubes, QD1-999
Chemistry, 3D stochastic microsensors, inulin, HRG-α, gold nanoparticles, HER-1, 3D stochastic microsensors; multi-walled carbon nanotubes; gold nanoparticles; inulin; HRG-α; HER-1; HER-2; HER-3; HER-4; brain cancer, multi-walled carbon nanotubes, QD1-999
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