Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
Copyright policy ) Bardelle, Catherine; Cross, Darren; Davenport, Sara; Kettle, Jason G.; Ko, Eun Jung; Leach, Andrew G.; Mortlock, Andrew; +4 Authors
Bardelle, Catherine; Cross, Darren; Davenport, Sara; Kettle, Jason G.; Ko, Eun Jung; Leach, Andrew G.; Mortlock, Andrew; Read, Jon; Roberts, Nicola J.; Robins, Peter; Williams, Emma J.;
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
A series of bis-anilinopyrimidines have been identified as potent inhibitors of the tyrosine kinase EphB4. Structural information from two alternative series identified from screening efforts was combined to identify the initial leads.
- AstraZeneca (United Kingdom) United Kingdom
- ASTRAZENECA UK LIMITED United Kingdom
- University of Salford United Kingdom
Aniline Compounds, kinase, Receptor, EphB4, EphB4, Hydrogen Bonding, structure-based design, Structure-Activity Relationship, Pyrimidines, Isomerism, Models, Chemical, Drug Design, lead identification, Protein Kinase Inhibitors
Aniline Compounds, kinase, Receptor, EphB4, EphB4, Hydrogen Bonding, structure-based design, Structure-Activity Relationship, Pyrimidines, Isomerism, Models, Chemical, Drug Design, lead identification, Protein Kinase Inhibitors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).52 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 52
Top 10%
Top 10%
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