Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter
Copyright policy )Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter
Head-to-head genes with a short distance between their transcription start sites may constitute up to 10% of all genes in the genomes of various species. It was hypothesized that this intergenic space may represent bidirectional promoters which are able to initiate transcription of both genes, but the true bidirectionality was proved only for a few of them. We present experimental evidence that, according to several criteria, a 269 bp region located between the PSENEN and U2AF1L4 human genes is a genuine bidirectional promoter regulating a concerted divergent transcription of these genes. Concerted transcription of PSENEN and U2AF1L4 can be necessary for regulation of T-cell activity.
- Russian Academy of Sciences Russian Federation
- Institute of Bioorganic Chemistry Russian Federation
- Institute of Molecular Genetics Russian Federation
- Department of Biological Sciences Russian Federation
Transcription, Genetic, Membrane Proteins, Nuclear Proteins, Splicing Factor U2AF, Cell Line, Protein Subunits, Gene Expression Regulation, Ribonucleoproteins, Organ Specificity, Consensus Sequence, Humans, Amyloid Precursor Protein Secretases, Cloning, Molecular, Nucleotide Motifs, Promoter Regions, Genetic
Transcription, Genetic, Membrane Proteins, Nuclear Proteins, Splicing Factor U2AF, Cell Line, Protein Subunits, Gene Expression Regulation, Ribonucleoproteins, Organ Specificity, Consensus Sequence, Humans, Amyloid Precursor Protein Secretases, Cloning, Molecular, Nucleotide Motifs, Promoter Regions, Genetic
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