Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Copyright policy )Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Iron-sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron-sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron-sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.
Iron-Sulfur Proteins, Iron Overload, Iron, Anemia, Sideroblastic, Mitochondria, Protein Structure, Tertiary, Evolution, Molecular, Mice, Friedreich Ataxia, Yeasts, Animals, Homeostasis, Humans
Iron-Sulfur Proteins, Iron Overload, Iron, Anemia, Sideroblastic, Mitochondria, Protein Structure, Tertiary, Evolution, Molecular, Mice, Friedreich Ataxia, Yeasts, Animals, Homeostasis, Humans
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