Paraoxonase Gene Polymorphism and the Risk for Alzheimer’s Disease in the Polish Population
Copyright policy )Paraoxonase Gene Polymorphism and the Risk for Alzheimer’s Disease in the Polish Population
<i>Background:</i> The relationship between different paraoxonase <i>(PON)</i> gene polymorphisms and the risk of Alzheimer’s disease (AD) was studied several times and the results were controversial. <i>Methods:</i> We investigated the association of 4 single-nucleotide polymorphisms (SNPs) of the <i>PON1</i> (M55L; Q192R; –161C/T) and the <i>PON2</i> (C311S) genes that were shown to affect the risk of sporadic AD. We studied 360 Caucasian cases with late-onset AD and 354 nondemented controls. <i>Results:</i> No significant differences were observed between the studied <i>PON</i> SNPs and AD risk. The results did not change after stratification of the apolipoprotein E status. Meta-analyses of studies in Caucasians assessing the associations between the <i>PON1 </i>M55L, –161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found. <i>Conclusion:</i> Our results suggest that the studied <i>PON1</i> and <i>PON2</i> polymorphisms are not associated with late-onset AD.
- Jagiellonian University Poland
- Polish Academy of Sciences Poland
- Polish Academy of Learning Poland
- Mossakowski Medical Research Centre Poland
Male, Polymorphism, Genetic, Genotype, Aryldialkylphosphatase, Population, Age Factors, DNA, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Apolipoproteins E, Gene Frequency, Haplotypes, Alzheimer Disease, Humans, Female, Poland, Age of Onset, Alleles, Aged
Male, Polymorphism, Genetic, Genotype, Aryldialkylphosphatase, Population, Age Factors, DNA, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Apolipoproteins E, Gene Frequency, Haplotypes, Alzheimer Disease, Humans, Female, Poland, Age of Onset, Alleles, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!