Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
Copyright policy )Alpha-2-Macroglobulin in Inflammation, Immunity and Infections
Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for endopeptidases of all catalytic types, alpha-2-macroglobulin lures active proteases into its molecular cage and subsequently ‘flags’ their complex for elimination. In addition to its role as a regulator of extracellular proteolysis, alpha-2-macroglobulin also has other functions such as switching proteolysis towards small substrates, facilitating cell migration and the binding of cytokines, growth factors and damaged extracellular proteins. These functions appear particularly important in the context of immune-cell function. In this review manuscript, we provide an overview of all functions of alpha-2-macroglobulin and place these in the context of inflammation, immunity and infections.
- KU Leuven Belgium
- Université Catholique de Louvain Belgium
- University of Oxford, Kennedy Institute of Rheumatology United Kingdom
- Katholieke Universiteit Leuven Belgium
- KATHOLIEKE UNIVERSITEIT LEUVEN Belgium
CELL-SURFACE GRP78, Neutrophils, TRYPANOSOMA-CRUZI, neutrophils, 1108 Medical Microbiology, Leukocytes, RECOGNIZED FORMS, infections, Complement Activation, Pregnancy-Associated alpha 2-Macroglobulins, macrophages, 3204 Immunology, 1107 Immunology, Cytokines, Intercellular Signaling Peptides and Proteins, Disease Susceptibility, Life Sciences & Biomedicine, alpha-2-macroglobulin, Protein Binding, Signal Transduction, MANNAN-BINDING LECTIN, TRANSFORMING GROWTH-FACTOR-BETA-1, 3101 Biochemistry and cell biology, proteolysis, RECEPTOR-RELATED PROTEIN, Immunology, Communicable Diseases, 3105 Genetics, Diagnosis, Differential, Endopeptidases, Animals, Humans, PHOSPHOLIPASE A(2) ACTIVITY, Inflammation, Science & Technology, GROWTH-FACTOR-BETA, Macrophages, Immunity, NECROSIS-FACTOR-ALPHA, Complement System Proteins, ALPHA(2)-MACROGLOBULIN SIGNALING RECEPTOR, RC581-607, immunity, inflammation, Proteolysis, Immunologic diseases. Allergy, Biomarkers
CELL-SURFACE GRP78, Neutrophils, TRYPANOSOMA-CRUZI, neutrophils, 1108 Medical Microbiology, Leukocytes, RECOGNIZED FORMS, infections, Complement Activation, Pregnancy-Associated alpha 2-Macroglobulins, macrophages, 3204 Immunology, 1107 Immunology, Cytokines, Intercellular Signaling Peptides and Proteins, Disease Susceptibility, Life Sciences & Biomedicine, alpha-2-macroglobulin, Protein Binding, Signal Transduction, MANNAN-BINDING LECTIN, TRANSFORMING GROWTH-FACTOR-BETA-1, 3101 Biochemistry and cell biology, proteolysis, RECEPTOR-RELATED PROTEIN, Immunology, Communicable Diseases, 3105 Genetics, Diagnosis, Differential, Endopeptidases, Animals, Humans, PHOSPHOLIPASE A(2) ACTIVITY, Inflammation, Science & Technology, GROWTH-FACTOR-BETA, Macrophages, Immunity, NECROSIS-FACTOR-ALPHA, Complement System Proteins, ALPHA(2)-MACROGLOBULIN SIGNALING RECEPTOR, RC581-607, immunity, inflammation, Proteolysis, Immunologic diseases. Allergy, Biomarkers
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