Spermatogenic failure of translocation heterozygotes affected by H–2-linked gene in mouse
Copyright policy )Spermatogenic failure of translocation heterozygotes affected by H–2-linked gene in mouse
ACCORDING to Lifschytz and Lindsley1,2, the basic control mechanism of spermatogenesis of all male heterogametic organisms consists of inactivation of the X chromosome during differentiation of germ cells. The absence of this control mechanism in female meiosis, where both X chromosomes are active3,4, could explain why only male gametogenesis is impaired in the carriers of some chromosomal aberrations.
- Institute of Molecular Genetics Russian Federation
- Jackson Laboratory United States
- Czech Academy of Sciences Czech Republic
- Czechoslovak Academy of Sciences Czech Republic
- Department of Biological Sciences Russian Federation
Male, Heterozygote, T locus - Talleles, Growth:, C57BL/6, Mice, Inbred Strains, Translocation, Genetic, Mice, F, Histocompatibility Antigens, Testis, CBA/H-T6T6, Animals, AKR, BALB/C, Spermatogenesis, Infertility, Male, Chromosome Aberrations, Genes: H-2 - Histocompatibility-2, T brachyury, C57BL/10, Sex Chromosomes, Physiology:, Chromosome Mapping, Organ Size, C3H, I, Organs:, Life-History Effects:, Genes, Hereditary Factors:, Strains: A(CAL-A) (A/J), Hst-1 - Hybrid sterility-1, CBA
Male, Heterozygote, T locus - Talleles, Growth:, C57BL/6, Mice, Inbred Strains, Translocation, Genetic, Mice, F, Histocompatibility Antigens, Testis, CBA/H-T6T6, Animals, AKR, BALB/C, Spermatogenesis, Infertility, Male, Chromosome Aberrations, Genes: H-2 - Histocompatibility-2, T brachyury, C57BL/10, Sex Chromosomes, Physiology:, Chromosome Mapping, Organ Size, C3H, I, Organs:, Life-History Effects:, Genes, Hereditary Factors:, Strains: A(CAL-A) (A/J), Hst-1 - Hybrid sterility-1, CBA
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