Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
Copyright policy )Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
We show thatDrosophilaexpresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/α2-macroglobulin superfamily. The genes are transcribed at a low level during all stages of development, and their expression is markedly up-regulated after an immune challenge. For one of these genes, which is predominantly expressed in the larval fat body, we observe a constitutive expression in gain-of-function mutants of the Janus kinase (JAK)hopand a reduced inducibility in loss-of-functionhopmutants. We also observe a constitutive expression in gain-of-functionTollmutants. We discuss the possible roles of these novel complement-like proteins in theDrosophilahost defense.
Membrane Glycoproteins, Sequence Homology, Amino Acid, Transcription, Genetic, Molecular Sequence Data, Toll-Like Receptors, Proteins, Esters, Receptors, Cell Surface, Complement C3, Protein-Tyrosine Kinases, Mutation, Animals, Drosophila Proteins, Insect Proteins, Drosophila, alpha-Macroglobulins, Amino Acid Sequence, Sulfhydryl Compounds, Janus Kinases, Transcription Factors
Membrane Glycoproteins, Sequence Homology, Amino Acid, Transcription, Genetic, Molecular Sequence Data, Toll-Like Receptors, Proteins, Esters, Receptors, Cell Surface, Complement C3, Protein-Tyrosine Kinases, Mutation, Animals, Drosophila Proteins, Insect Proteins, Drosophila, alpha-Macroglobulins, Amino Acid Sequence, Sulfhydryl Compounds, Janus Kinases, Transcription Factors
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