Lysophosphatidic acid induces neurite branch formation through LPA3
Copyright policy )Lysophosphatidic acid induces neurite branch formation through LPA3
Although neurite branching is crucial for neuronal network formation after birth, its underlying mechanisms remain unclear. Here, we demonstrate that lysophosphatidic acid (LPA) stimulates neurite branching through a novel signaling pathway. Treatment of neuronal cell lines with LPA resulted in neurite branch formation when LPA(3) receptor was introduced. The effects of LPA were blocked by inhibition of G(q) signaling. Furthermore, expression of inhibitory mutants of the small GTPase Rnd2/Rho7 or an Rnd2 effector rapostlin abolished LPA(3)-mediated neurite branching. The LPA(3) agonist 2(S)-OMPT or LPA also induced axonal branch formation in hippocampal neurons, which was blocked by G(q) and Rnd2 pathway inhibition or LPA(3) knockdown. These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation.
- Kindai University Japan
Neurons, rho GTP-Binding Proteins, 3T3 Cells, PC12 Cells, Rats, Mice, Neurites, Tumor Cells, Cultured, Animals, GTP-Binding Protein alpha Subunits, Gq-G11, Lysophospholipids, RNA, Small Interfering, Receptors, Lysophosphatidic Acid
Neurons, rho GTP-Binding Proteins, 3T3 Cells, PC12 Cells, Rats, Mice, Neurites, Tumor Cells, Cultured, Animals, GTP-Binding Protein alpha Subunits, Gq-G11, Lysophospholipids, RNA, Small Interfering, Receptors, Lysophosphatidic Acid
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).28 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!