Looking at mRNA decay pathways through the window of molecular evolution
Copyright policy )Looking at mRNA decay pathways through the window of molecular evolution
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.
- University of Wisconsin–Oshkosh United States
- University of Wisconsin–Madison United States
Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Evolution, Molecular, Sequence Analysis, Protein, Trans-Activators, Animals, Humans, RNA, Messenger, Sequence Alignment, Phylogeny, RNA Helicases
Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Evolution, Molecular, Sequence Analysis, Protein, Trans-Activators, Animals, Humans, RNA, Messenger, Sequence Alignment, Phylogeny, RNA Helicases
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