Expression of Constitutively Activated Giα2 in Vivo Ameliorates Streptozotocin-induced Diabetes
Copyright policy )Expression of Constitutively Activated Giα2 in Vivo Ameliorates Streptozotocin-induced Diabetes
Streptozotocin treatment in vivo generates a model of insulin-dependent diabetes mellitus via destruction of the pancreatic beta-cells responsible for insulin secretion. Tissue-specific expression of the Q205L constitutively activated mutant form of the G-protein Gialpha2 in vivo ameliorates streptozotocin-induced insulin-dependent diabetes mellitus in transgenic mice. Conditional expression of Q205L Gialpha2 in vivo in liver, skeletal muscle, and adipose tissue markedly rectifies glucose tolerance, fasting glucose levels, and glycogen synthase activation in the mice with insulin-dependent diabetes mellitus, providing a novel therapeutic target for diabetes.
- Stony Brook University United States
- University Medical Center United States
Blood Glucose, Mice, Transgenic, GTP-Binding Protein alpha Subunits, Gi-Go, Glucose Tolerance Test, Diabetes Mellitus, Experimental, Rats, Mice, Diabetes Mellitus, Type 1, Glycogen Synthase, Adipose Tissue, Liver, Animals, Point Mutation, Muscle, Skeletal
Blood Glucose, Mice, Transgenic, GTP-Binding Protein alpha Subunits, Gi-Go, Glucose Tolerance Test, Diabetes Mellitus, Experimental, Rats, Mice, Diabetes Mellitus, Type 1, Glycogen Synthase, Adipose Tissue, Liver, Animals, Point Mutation, Muscle, Skeletal
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