Investigations of CHD1 Function in Transcription and Development of Drosophila melanogaster
Copyright policy )Investigations of CHD1 Function in Transcription and Development of Drosophila melanogaster
Abstract In this report we describe chd1 mutant alleles and show that the CHD1 chromatin-remodeling factor is important for wing development and fertility. While CHD1 colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes, elongating Pol II can persist on chromatin in the absence of CHD1. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function.
- Scripps College United States
- Claremont McKenna College United States
- Scripps Health United States
- Pitzer College United States
- W.M. Keck Science Center United States
Homeodomain Proteins, Male, Genes, Essential, Transcription, Genetic, DNA Helicases, Chromosomes, DNA-Binding Proteins, Drosophila melanogaster, Fertility, Oogenesis, Mutation, Animals, Drosophila Proteins, Wings, Animal, Female, Alleles, Protein Binding, Transcription Factors
Homeodomain Proteins, Male, Genes, Essential, Transcription, Genetic, DNA Helicases, Chromosomes, DNA-Binding Proteins, Drosophila melanogaster, Fertility, Oogenesis, Mutation, Animals, Drosophila Proteins, Wings, Animal, Female, Alleles, Protein Binding, Transcription Factors
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