Translational animal models of autism and neurodevelopmental disorders
Copyright policy )Translational animal models of autism and neurodevelopmental disorders
Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral criteria: unusual reciprocal social interactions, deficits in communication, and stereotyped repetitive behaviors with restricted interests. A large number of de novo single gene mutations and chromosomal deletions are associated with autism spectrum disorders. Based on the strong genetic evidence, mice with targeted mutations in homologous genes have been generated as translational research tools. Mouse models of autism have revealed behavioral and biological outcomes of mutations in risk genes. The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics.
- University of California, Davis United States
- University of California, San Francisco United States
- University of California System United States
Biomedical, Autism, Developmental Disabilities, Chromosome Disorders, mGluRS antagonist, Translational Research, Biomedical, Mice, self-grooming, therapeutics, 2.1 Biological and endogenous factors, genetics, Aetiology, Pediatric, Psychiatry, repetitive behavior, anxiety, olfactory, Mental Health, Mental health, Biotechnology, Intellectual and Developmental Disabilities (IDD), mouse model, 610, autism, tuberous sclerosis, social behavior, cognitive, 616, Behavioral and Social Science, Translational Research, Genetics, Animals, Humans, Autistic Disorder, Other Medical and Health Sciences, Biomedical and Clinical Sciences, Animal, Neurosciences, Social Behavior Disorders, neurodevelopmental disorder, Brain Disorders, ultrasonic vocalization, Disease Models, Animal, Disease Models, Fragile X, Mutation, Biological psychology, Gene Deletion
Biomedical, Autism, Developmental Disabilities, Chromosome Disorders, mGluRS antagonist, Translational Research, Biomedical, Mice, self-grooming, therapeutics, 2.1 Biological and endogenous factors, genetics, Aetiology, Pediatric, Psychiatry, repetitive behavior, anxiety, olfactory, Mental Health, Mental health, Biotechnology, Intellectual and Developmental Disabilities (IDD), mouse model, 610, autism, tuberous sclerosis, social behavior, cognitive, 616, Behavioral and Social Science, Translational Research, Genetics, Animals, Humans, Autistic Disorder, Other Medical and Health Sciences, Biomedical and Clinical Sciences, Animal, Neurosciences, Social Behavior Disorders, neurodevelopmental disorder, Brain Disorders, ultrasonic vocalization, Disease Models, Animal, Disease Models, Fragile X, Mutation, Biological psychology, Gene Deletion
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