Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK
Copyright policy )Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK
Exposure of the yeast Saccharomyces cerevisiae to high extracellular osmolarity induces the Sln1p-Ypd1p-Ssk1p two-component osmosensor to activate a mitogen-activated protein (MAP) kinase cascade composed of the Ssk2p and Ssk22p MAP kinase kinase kinases (MAPKKKs), the Pbs2p MAPKK, and the Hog1p MAPK. A second osmosensor, Sho1p, also activated Pbs2p and Hog1p, but did so through the Ste11p MAPKKK. Although Ste11p also participates in the mating pheromone–responsive MAPK cascade, there was no detectable cross talk between these two pathways. The MAPKK Pbs2p bound to the Sho1p osmosensor, the MAPKKK Ste11p, and the MAPK Hog1p. Thus, Pbs2p may serve as a scaffold protein.
- Dana-Farber Cancer Institute United States
- Harvard University United States
Mitogen-Activated Protein Kinase Kinases, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Genes, Fungal, Genetic Complementation Test, Osmolar Concentration, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, MAP Kinase Kinase Kinases, Enzyme Activation, Osmotic Pressure, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Mitogen-Activated Protein Kinases, Phosphorylation, Mating Factor, Peptides, Protein Kinases, Signal Transduction
Mitogen-Activated Protein Kinase Kinases, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Genes, Fungal, Genetic Complementation Test, Osmolar Concentration, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, MAP Kinase Kinase Kinases, Enzyme Activation, Osmotic Pressure, Calcium-Calmodulin-Dependent Protein Kinases, Mutation, Mitogen-Activated Protein Kinases, Phosphorylation, Mating Factor, Peptides, Protein Kinases, Signal Transduction
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