Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome
Copyright policy )Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome
The purpose of the present study was to identify genetic variants that confer susceptibility to chronic kidney disease (CKD) in Japanese individuals with metabolic syndrome. The study population comprised 2150 Japanese individuals with metabolic syndrome, including 411 subjects with CKD [estimated glomerular filtration rate (eGFR) /=60 mL/min/1.73m(2)). The genotypes for 100 polymorphisms of 80 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that nine polymorphisms of APOE, ABCA1, PTGS1, TNF, CPB2, AGTR1, OR13G1, and GNB3 were associated (PT polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome.
- Hirosaki University Japan
- Tokyo Metropolitan Institute of Gerontology Japan
- Gifu Prefectural General Medical Center Japan
- Mie University Japan
- International Institute of Minnesota United States
Aged, 80 and over, Male, Metabolic Syndrome, Polymorphism, Genetic, Genotype, Middle Aged, Metabolic syndrome, Apolipoproteins E, Logistic Models, Genetic, Asian People, Chronic kidney disease, Genetics, Humans, Female, Genetic Predisposition to Disease, Apolipoprotein E, Polymorphism, Renal Insufficiency, Chronic, Alleles, Aged
Aged, 80 and over, Male, Metabolic Syndrome, Polymorphism, Genetic, Genotype, Middle Aged, Metabolic syndrome, Apolipoproteins E, Logistic Models, Genetic, Asian People, Chronic kidney disease, Genetics, Humans, Female, Genetic Predisposition to Disease, Apolipoprotein E, Polymorphism, Renal Insufficiency, Chronic, Alleles, Aged
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