Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice
Copyright policy )Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice
Acute promyelocytic leukemia (APL) is a model system of aberrant transcription in cancer. We sought to elucidate the mechanism of action of the variant fusion NuMA-RARα in APL, using the hCG-NuMA-RARα transgenic model. We report that subcellular localization of NuMA-RARα in transgenic mice is dependent upon its protein expression and transgene dosage. Subcellular localization of the fusion is inversely correlated with extent of gene deregulation at the mRNA level for Cebpα, Cebpɛ and Pu.1. Finally, we report that phenotype onset is correlated with NuMA-RARα copy number; mice with higher copy number developing disease later than those with lower copy number.
- Sunnybrook Health Science Centre Canada
- University Health Network Canada
- University of Toronto Canada
- Ontario Institute for Cancer Research Canada
- Princess Margaret Cancer Centre Canada
Cell Nucleus, Cytoplasm, Leukemia, Oncogene Proteins, Fusion, Gene Expression Regulation, Leukemic, Gene Dosage, Mice, Transgenic, U937 Cells, Chorionic Gonadotropin, Disease Models, Animal, Mice, Protein Transport, Phenotype, Animals, Humans, Transgenes
Cell Nucleus, Cytoplasm, Leukemia, Oncogene Proteins, Fusion, Gene Expression Regulation, Leukemic, Gene Dosage, Mice, Transgenic, U937 Cells, Chorionic Gonadotropin, Disease Models, Animal, Mice, Protein Transport, Phenotype, Animals, Humans, Transgenes
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!