SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
Copyright policy )SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans
We describe the identification and characterization of a novel gene, sur-8, that positively regulates Ras-mediated signal transduction during C. elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutation. sur-8 appears to act downstream of or in parallel to ras but upstream of raf. sur-8 encodes a conserved protein that is composed predominantly of leucine-rich repeats. The SUR-8 protein interacts directly with Ras but not with the Ras(P34G) mutant protein, suggesting that SUR-8 may mediate its effects through Ras binding. A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro.
- University of Colorado Boulder United States
- Howard Hughes Medical Institute United States
- UNIVERSITY OF COLORADO AT BOULDER
Embryonic Induction, Mammals, Mitogen-Activated Protein Kinase 1, Biochemistry, Genetics and Molecular Biology(all), Molecular Sequence Data, Gene Dosage, Protein Serine-Threonine Kinases, Phenotype, Leucine, Mutation, Animals, Female, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carrier Proteins, Protein Kinases, Conserved Sequence, Genes, Helminth, Adaptor Proteins, Signal Transducing, Protein Binding
Embryonic Induction, Mammals, Mitogen-Activated Protein Kinase 1, Biochemistry, Genetics and Molecular Biology(all), Molecular Sequence Data, Gene Dosage, Protein Serine-Threonine Kinases, Phenotype, Leucine, Mutation, Animals, Female, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carrier Proteins, Protein Kinases, Conserved Sequence, Genes, Helminth, Adaptor Proteins, Signal Transducing, Protein Binding
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