Relaying the Checkpoint Signal from Kinetochore to APC/C
Copyright policy )Relaying the Checkpoint Signal from Kinetochore to APC/C
The mitotic checkpoint delays chromosome segregation until the last chromosome has correctly attached to the spindle. Exactly how this unattached chromosome can generate a checkpoint signal and inhibit the anaphase promoting complex/cyclosome (APC/C) is unknown. Two Developmental Cell papers in this issue by Kulukian et al. and Malureanu et al. now provide insight into how checkpoint components Mad2 and BubR1 relay the checkpoint signal from kinetochores to APC/C.
- Utrecht University Netherlands
- University Museum Utrecht Netherlands
- University Medical Center Utrecht Netherlands
Chromosome Segregation, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Spindle Apparatus, Kinetochores, Anaphase-Promoting Complex-Cyclosome, Chromosomes, Developmental Biology, Signal Transduction
Chromosome Segregation, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Spindle Apparatus, Kinetochores, Anaphase-Promoting Complex-Cyclosome, Chromosomes, Developmental Biology, Signal Transduction
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