Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
Copyright policy )Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
Significance The TGF-β family encompasses a large number of secreted proteins that regulate embryonic development and adult tissue homeostasis. Growth and differentiation factor (GDF) -associated serum protein-1 (GASP-1) and GASP-2 are related proteins capable of binding and inhibiting two family members, myostatin and GDF-11. Here, we show that mice genetically engineered to lack GASP-1 and/or GASP-2 exhibit muscle and skeletal phenotypes consistent with overactivity of myostatin and/or GDF-11. These studies also reveal the enormous complexity of this regulatory system in vivo and the delicate balance that must be maintained between signaling molecules and their inhibitory proteins for proper levels of signaling to be achieved.
- Johns Hopkins Medicine United States
- Johns Hopkins University School of Medicine United States
Follistatin, Gene Expression Profiling, Muscle Fibers, Skeletal, Intracellular Signaling Peptides and Proteins, Organ Size, Myostatin, Cardiotoxins, Bone and Bones, Mice, Mutant Strains, Growth Differentiation Factors, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Bone Morphogenetic Proteins, Mutation, Animals, Carrier Proteins, Oxidation-Reduction, Body Patterning, Protein Binding
Follistatin, Gene Expression Profiling, Muscle Fibers, Skeletal, Intracellular Signaling Peptides and Proteins, Organ Size, Myostatin, Cardiotoxins, Bone and Bones, Mice, Mutant Strains, Growth Differentiation Factors, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Bone Morphogenetic Proteins, Mutation, Animals, Carrier Proteins, Oxidation-Reduction, Body Patterning, Protein Binding
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