TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
Copyright policy )TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
Inflammation and innate immunity may play a role in the pathogenesis of atherosclerosis. The Asp299Gly polymorphism in the toll-like receptor 4 (TLR4) gene reduces responsiveness to lipopolysaccharide and has been associated with reduced incidence and slower progression of carotid atherosclerosis. We analyzed this polymorphism in relation to susceptibility to and severity of coronary artery disease.1400 participants (mean age: 63 years, 31% female) in the Southampton Atherosclerosis Study were genotyped for the TLR4 Asp299Gly polymorphism using the tetra-primer PCR method.There was no significant difference between the frequencies of the Asp/Gly or Gly/Gly genotypes combined, compared to the Asp/Asp genotype, in patients with 0, 1, 2 or 3 coronary arteries with >50% stenosis (chi2(3 d.f.)2=0.4, P=0.94). No associations were observed between genotype groups and cardiac risk factors (P>0.05).The findings of this study do not support the hypothesis that the TLR4 Asp299Gly polymorphism influences predisposition to and progression of coronary artery disease.
- University of Southampton United Kingdom
- University of Queensland Australia
- University of Queensland Australia
Male, Coronary disease, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Statistics as Topic, Toll-Like Receptors, Coronary Stenosis, 610, Receptors, Cell Surface, Middle Aged, Toll-like receptor 4, Severity of Illness Index, Toll-Like Receptor 4, Logistic Models, Gene Frequency, Risk Factors, Peripheral vascular disease, Humans, Female, Genetic Predisposition to Disease, Polymorphism (genetics)
Male, Coronary disease, Membrane Glycoproteins, Polymorphism, Genetic, Genotype, Statistics as Topic, Toll-Like Receptors, Coronary Stenosis, 610, Receptors, Cell Surface, Middle Aged, Toll-like receptor 4, Severity of Illness Index, Toll-Like Receptor 4, Logistic Models, Gene Frequency, Risk Factors, Peripheral vascular disease, Humans, Female, Genetic Predisposition to Disease, Polymorphism (genetics)
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).103 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!