CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
Copyright policy )CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
- University of California System United States
- Inserm France
- King's College London United Kingdom
- University of Paris France
- University of Queensland Australia
Monocytes/cytology, Nitric Oxide Synthase Type II, Macrophages/immunology, Monocytes, Mice, Inflammation/enzymology, Spleen/cytology, Cell Movement, /dk/atira/pure/subjectarea/asjc/2700/2723, Immunology and Allergy, Listeriosis, /dk/atira/pure/subjectarea/asjc/2400/2403, Stem Cells, Dendritic Cells/enzymology, Cell Differentiation, Receptors, Chemokine/metabolism, Inflammation/immunology, Listeriosis/immunology, Phenotype, Receptors, Chemokine, Nitric Oxide Synthase Type II/metabolism, [SDV.IMM] Life Sciences [q-bio]/Immunology, Cell Survival, Macrophages/enzymology, Immunology, CX3C Chemokine Receptor 1, 610, Bone Marrow Cells/cytology, Tumor Necrosis Factor-alpha/biosynthesis, Bone Marrow Cells, Receptor, Macrophage Colony-Stimulating Factor, Dendritic Cells/cytology, Article, Reactive Oxygen Species/metabolism, Animals, Receptor, Macrophage Colony-Stimulating Factor/metabolism, Cell Proliferation, Inflammation, fms-Like Tyrosine Kinase 3/metabolism, Macrophages, Macrophages/cytology, Monocytes/immunology, Dendritic Cells, Listeria monocytogenes, Receptors, Chemokine/deficiency, Dendritic Cells/immunology, Reactive Oxygen Species, Bone Marrow Cells/immunology, Spleen
Monocytes/cytology, Nitric Oxide Synthase Type II, Macrophages/immunology, Monocytes, Mice, Inflammation/enzymology, Spleen/cytology, Cell Movement, /dk/atira/pure/subjectarea/asjc/2700/2723, Immunology and Allergy, Listeriosis, /dk/atira/pure/subjectarea/asjc/2400/2403, Stem Cells, Dendritic Cells/enzymology, Cell Differentiation, Receptors, Chemokine/metabolism, Inflammation/immunology, Listeriosis/immunology, Phenotype, Receptors, Chemokine, Nitric Oxide Synthase Type II/metabolism, [SDV.IMM] Life Sciences [q-bio]/Immunology, Cell Survival, Macrophages/enzymology, Immunology, CX3C Chemokine Receptor 1, 610, Bone Marrow Cells/cytology, Tumor Necrosis Factor-alpha/biosynthesis, Bone Marrow Cells, Receptor, Macrophage Colony-Stimulating Factor, Dendritic Cells/cytology, Article, Reactive Oxygen Species/metabolism, Animals, Receptor, Macrophage Colony-Stimulating Factor/metabolism, Cell Proliferation, Inflammation, fms-Like Tyrosine Kinase 3/metabolism, Macrophages, Macrophages/cytology, Monocytes/immunology, Dendritic Cells, Listeria monocytogenes, Receptors, Chemokine/deficiency, Dendritic Cells/immunology, Reactive Oxygen Species, Bone Marrow Cells/immunology, Spleen
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