Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
Copyright policy )Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired(upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.
- Howard Hughes Medical Institute United States
- Harvard University United States
- University of Kentucky United States
- Takeda (Japan) Japan
- ARIAD Pharmaceuticals (United States) United States
570, Embryo, Nonmammalian, Molecular Sequence Data, Genes, Insect, Research Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biology, 616, Animals, Drosophila Proteins, Amino Acid Sequence, Base Pairing, Glycoproteins, Janus Kinases, Extracellular Matrix Proteins, Base Sequence, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, DNA-Binding Proteins, STAT Transcription Factors, Cytokines, Insect Proteins, Drosophila, Signal Transduction
570, Embryo, Nonmammalian, Molecular Sequence Data, Genes, Insect, Research Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Developmental biology, 616, Animals, Drosophila Proteins, Amino Acid Sequence, Base Pairing, Glycoproteins, Janus Kinases, Extracellular Matrix Proteins, Base Sequence, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, DNA-Binding Proteins, STAT Transcription Factors, Cytokines, Insect Proteins, Drosophila, Signal Transduction
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