Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
Copyright policy ) Pauline C, Ting; Joe F, Lee; Nicolas, Zorn; Hyunjin M, Kim; Robert G, Aslanian; Mingxiang, Lin; Michelle, Smith; +4 Authors
Pauline C, Ting; Joe F, Lee; Nicolas, Zorn; Hyunjin M, Kim; Robert G, Aslanian; Mingxiang, Lin; Michelle, Smith; Scott S, Walker; John, Cook; Margaret, Van Heek; Jean, Lachowicz;
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.
- Merck & Co. United States
Mice, Structure-Activity Relationship, Pyridines, Animals, Humans, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Amides
Mice, Structure-Activity Relationship, Pyridines, Animals, Humans, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Amides
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Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 8
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