SKD1 AAA ATPase-Dependent Endosomal Transport is Involved in Autolysosome Formation.
Copyright policy )SKD1 AAA ATPase-Dependent Endosomal Transport is Involved in Autolysosome Formation.
Mouse SKD1 AAA ATPase is involved in the sorting and transport from endosomes; cells overexpressing a dominant-negative mutant, SKD1(E235Q) were defective in endosomal transport to both the plasma membranes and lysosomes (Yoshimori et al., 2000). In the present study, we demonstrated that overexpression of SKD1(E235Q) using an adenovirus delivery system caused a defect in autophagy-dependent bulk protein degradation. Morphological observations suggested that this inhibition of autophagy results from an impairment of autolysosome formation. SKD1(E235Q) overexpression also inhibited transport from endosomes to autophagosomes, an event normally occurring prior to fusion with lysosomes. These results indicate that SKD1-dependent endosomal membrane trafficking is required for formation of autolysosomes.
Adenosine Triphosphatases, Vacuolar Proton-Translocating ATPases, Endosomal Sorting Complexes Required for Transport, Vesicular Transport Proteins, Biological Transport, Endosomes, Lipid Metabolism, Membrane Fusion, Adenoviridae, Repressor Proteins, Amino Acid Substitution, Phagosomes, Autophagy, ATPases Associated with Diverse Cellular Activities, Humans, Point Mutation, Lysosomes, HeLa Cells
Adenosine Triphosphatases, Vacuolar Proton-Translocating ATPases, Endosomal Sorting Complexes Required for Transport, Vesicular Transport Proteins, Biological Transport, Endosomes, Lipid Metabolism, Membrane Fusion, Adenoviridae, Repressor Proteins, Amino Acid Substitution, Phagosomes, Autophagy, ATPases Associated with Diverse Cellular Activities, Humans, Point Mutation, Lysosomes, HeLa Cells
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