SOCS in situ expression in tuberculous lymphadenitis in an endemic area
Copyright policy )SOCS in situ expression in tuberculous lymphadenitis in an endemic area
The immune response to Mycobacterium tuberculosis is complex and multifactorial, the cytokine system being a major factor in M. tuberculosis immunity.To analyze the immunohistochemical aspects of tuberculous lymph nodes in immunocompetent patients and search for associations between SOCS and cytokine expression in human tuberculous lymphadenitis.Thirteen lymph nodes were assayed by immunohistochemistry for SOCS-1 and 3, STAT-3, RANTES, MIP-1-alpha, ICAM-1, IFN-gamma as well as CD45RO, CD20, CD34, CD68, trypsin and lysozyme. Additionally, the RT in situ PCR was performed for SOCS-1 and 3 mRNA detection.Decreased MIP-1 alpha expression together with reduced SOCS-3 (p=0.042), lysozyme (p=0.024) and CD45RO (p=0.05) was observed in the TB lymph nodes compared to the control lymph nodes. In conclusion, the lymphadenitis due to M. tuberculosis was associated with a downregulation of memory T cells (CD45RO), activated lysozymes and SOCS-3 compared to controls, which may play a role in the long-term bacterial replication and altered immune modulation characteristic of the disease.
- Oswaldo Cruz Foundation Brazil
Adult, Adolescent, Endemic Diseases, Suppressor of Cytokine Signaling Proteins, Mycobacterium tuberculosis, Middle Aged, Tuberculosis, Lymph Node, Immunohistochemistry, Suppressor of Cytokine Signaling 1 Protein, Antigens, CD, Suppressor of Cytokine Signaling 3 Protein, Cytokines, Humans, Muramidase, Trypsin, Lymph Nodes, RNA, Messenger, Aged
Adult, Adolescent, Endemic Diseases, Suppressor of Cytokine Signaling Proteins, Mycobacterium tuberculosis, Middle Aged, Tuberculosis, Lymph Node, Immunohistochemistry, Suppressor of Cytokine Signaling 1 Protein, Antigens, CD, Suppressor of Cytokine Signaling 3 Protein, Cytokines, Humans, Muramidase, Trypsin, Lymph Nodes, RNA, Messenger, Aged
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