Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid Levator Muscle Development and Congenital Blepharophimosis
Copyright policy )Wakayama Symposium: Notch-FoxL2-α-SMA Axis in Eyelid Levator Muscle Development and Congenital Blepharophimosis
This review summarizes our recent findings regarding the Notch signaling pathway in regulating normal eyelid morphogenesis and its role in the pathogenesis of human congenital blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). We used genetic and molecular biological approaches to investigate the mechanism by which Notch1 activation controls expression of FoxL2, which in turn activates smooth muscle actin gene expression in periocular mesenchyma to control eyelid levator smooth muscle formation.
- University of Cincinnati United States
- University System of Ohio United States
Forkhead Box Protein L2, Eyelids, Humans, Forkhead Transcription Factors, Blepharophimosis, Receptor, Notch1, Muscle, Skeletal, Actins
Forkhead Box Protein L2, Eyelids, Humans, Forkhead Transcription Factors, Blepharophimosis, Receptor, Notch1, Muscle, Skeletal, Actins
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