Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population
Copyright policy )Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population
A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.
- Roma Tre University Italy
- Sapienza University of Rome Italy
- Komatsu University Japan
- Kanazawa University Japan
- Okayama University of Science Japan
Adult, Male, Genotype, Science, Q, R, Middle Aged, Polymorphism, Single Nucleotide, Cross-Sectional Studies, Asian People, Gene Frequency, Japan, Receptors, Adrenergic, beta-3, Hypertension, Medicine, Humans, Female, Genetic Predisposition to Disease, Insulin Resistance, Research Article, Aged
Adult, Male, Genotype, Science, Q, R, Middle Aged, Polymorphism, Single Nucleotide, Cross-Sectional Studies, Asian People, Gene Frequency, Japan, Receptors, Adrenergic, beta-3, Hypertension, Medicine, Humans, Female, Genetic Predisposition to Disease, Insulin Resistance, Research Article, Aged
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