Upregulation of Platelet Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase by Interferon Alpha
Copyright policy )Upregulation of Platelet Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase by Interferon Alpha
Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.
- Amsterdam UMC Netherlands
- Vrije Universiteit Amsterdam Netherlands
- Amsterdam University Medical Centers Netherlands
- Amsterdam UMC, location VUmc Netherlands
Thymidine Phosphorylase, Time Factors, Reverse Transcriptase Polymerase Chain Reaction, Interferon-alpha, Catalysis, Up-Regulation, Cell Line, Tumor, Cytokines, Humans, Interferons, RNA, Messenger, HT29 Cells, Uridine, DNA Damage
Thymidine Phosphorylase, Time Factors, Reverse Transcriptase Polymerase Chain Reaction, Interferon-alpha, Catalysis, Up-Regulation, Cell Line, Tumor, Cytokines, Humans, Interferons, RNA, Messenger, HT29 Cells, Uridine, DNA Damage
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