Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis
Copyright policy )Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis
We have isolated a mouse lysyl oxidase-like (LOXL) cDNA from a mouse embryo cDNA library and used this cDNA to measure changes in steady state levels of LOXL mRNA during the development of carbon tetrachloride-induced liver fibrosis in adult mice. These results revealed the coincident appearance of increased steady state levels of LOXL mRNA and type III procollagen mRNA early in the development of liver fibrosis. In contrast, steady state levels of lysyl oxidase mRNA increased throughout the onset of hepatic fibrosis and appeared in parallel with the increased steady state levels of pro-alphaI (I) collagen mRNA. These findings suggest that the LOXL protein (possibly an isoform of lysyl oxidase) is involved in the development of lysine-derived cross-links in collagenous substrates. Moreover, the substrate specificity of the LOXL protein may be different to that of lysyl oxidase and this difference may be collagen-type specific.
- University of Hawaiʻi Sea Grant United States
- Institut Pasteur France
- University of Hawaii System United States
- University of Hawaii at Manoa United States
- National Oceanic and Atmospheric Administration United States
Liver Cirrhosis, Male, Base Sequence, Dose-Response Relationship, Drug, Molecular Sequence Data, Gene Expression, Sequence Analysis, DNA, Blotting, Northern, Liver Cirrhosis, Experimental, Immunohistochemistry, Elastin, Protein-Lysine 6-Oxidase, Mice, Liver, Animals, Humans, RNA, Carbon Tetrachloride, Procollagen, Gene Library
Liver Cirrhosis, Male, Base Sequence, Dose-Response Relationship, Drug, Molecular Sequence Data, Gene Expression, Sequence Analysis, DNA, Blotting, Northern, Liver Cirrhosis, Experimental, Immunohistochemistry, Elastin, Protein-Lysine 6-Oxidase, Mice, Liver, Animals, Humans, RNA, Carbon Tetrachloride, Procollagen, Gene Library
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