Distribution of CCR5‐Δ32 and CCR2–64I alleles in an Argentine Amerindian population
Copyright policy )Distribution of CCR5‐Δ32 and CCR2–64I alleles in an Argentine Amerindian population
Abstract: In order to evaluate the frequency distributions of CCR5‐Δ32 and CCR2–64I polymorphisms in an Amerindian population, we tested a total of 42 Chiriguanos individuals that are aboriginal inhabitants of the north west of Argentina. Only one carried the CCR5‐Δ32 allele (0.0238), while 17 out of 35 carried the CCR2–64I mutation, including one homozygous for the mutated allele (0.2571). Although the cohort studied is considered highly endogamic, the HLA genotyping revealed that 8 out of 42 subjects had a gene flow from Caucasian populations. The only heterozygous CCR5+/Δ32 found and three heterozygous CCR2+/64I belonged to the admix group. In conclusion, the protective deletion CCR5‐Δ32 is practically absent in Chiriguanos whereas the CCR2–64I allele is highly frequent.
- Garrahan Hospital Argentina
- Hospital de Clínicas "José de San Martín" Argentina
Polymorphism, Genetic, Genotype, Receptors, CCR5, Receptors, CCR2, Indians, South American, Argentina, Humans, Receptors, Chemokine, Alleles
Polymorphism, Genetic, Genotype, Receptors, CCR5, Receptors, CCR2, Indians, South American, Argentina, Humans, Receptors, Chemokine, Alleles
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