MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells
Copyright policy )MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells
Epithelial cells act as the first line of host defense against microbes by producing a range of different molecules for clearance. Chemokines facilitate the clearance of invaders through the recruitment of leukocytes. Thus, upregulation of chemokine expression represents an important innate host defense response against invading microbes such as Streptococcus pneumoniae. In this study, we report that the expression of Monocyte Chemotactic Protein 1 (MCP1) was highly induced in response to S. pneumoniae in vitro and in vivo. Among numerous virulence factors, pneumococcal pneumolysin was found to be the major factor responsible for this induction. Furthermore, MCP1 induction was mediated by the p38 mitogen-activated protein kinase (MAPK) whose activation was controlled by MAPK phosphatase 1 (MKP1). Therefore, this study reveals novel roles of pneumolysin in mediating MKP1 expression for the regulation of MCP1 expression in human epithelial cells.
- University of Florida United States
- Korea University Japan
- Korea University Korea (Republic of)
- University of Rochester Medical Center United States
Virulence, Dual Specificity Phosphatase 1, Epithelial Cells, p38 Mitogen-Activated Protein Kinases, Immunity, Innate, Cell Line, Mice, Inbred C57BL, Mice, Streptococcus pneumoniae, Bacterial Proteins, Gene Expression Regulation, Streptococcal Infections, Streptolysins, Animals, Humans, RNA, Small Interfering, Chemokine CCL2
Virulence, Dual Specificity Phosphatase 1, Epithelial Cells, p38 Mitogen-Activated Protein Kinases, Immunity, Innate, Cell Line, Mice, Inbred C57BL, Mice, Streptococcus pneumoniae, Bacterial Proteins, Gene Expression Regulation, Streptococcal Infections, Streptolysins, Animals, Humans, RNA, Small Interfering, Chemokine CCL2
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!