Ena/VASP Is Required for Neuritogenesis in the Developing Cortex
Copyright policy )Ena/VASP Is Required for Neuritogenesis in the Developing Cortex
Mammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive these processes is fundamental to our understanding of cortical development. Here we show that loss of all three murine Ena/VASP proteins, a family of actin regulatory proteins, causes neuronal ectopias, alters intralayer positioning in the cortical plate, and, surprisingly, blocks axon fiber tract formation during corticogenesis. Cortical fiber tract defects in the absence of Ena/VASP arise from a failure in neurite initiation, a prerequisite for axon formation. Neurite initiation defects in Ena/VASP-deficient neurons are preceded by a failure to form bundled actin filaments and filopodia. These findings provide insight into the regulation of neurite formation and the role of the actin cytoskeleton during cortical development.
- University of Wisconsin–Madison United States
- Johns Hopkins Medicine United States
- National Cancer Institute United States
- Stanford University United States
- University of Wisconsin System United States
Male, Cell-Differentiation, 570, Neuroscience(all), Growth Cones, DEVBIO, Mice-Inbred-BALB-C, Cerebral-Cortex, Nervous System Malformations, MOLNEURO, Mice, Cell Movement, 616, Neural Pathways, Neurites, Animals, Pseudopodia, Cell-Movement, Microfilaments, Microfilament-Proteins, Cells, Cultured, Neural-Pathways, Body Patterning, Cerebral Cortex, Mice, Knockout, Body-Patterning, Mice, Inbred BALB C, Chimera, Growth-Cones, Mice-Inbred-C57BL, Microfilament Proteins, Cell Differentiation, Mice-Knockout, Phosphoproteins, Mice, Inbred C57BL, Actin Cytoskeleton, Nervous-System-Malformations, Cells-Cultured, Mutation, Female, Cell-Adhesion-Molecules, Cell Adhesion Molecules
Male, Cell-Differentiation, 570, Neuroscience(all), Growth Cones, DEVBIO, Mice-Inbred-BALB-C, Cerebral-Cortex, Nervous System Malformations, MOLNEURO, Mice, Cell Movement, 616, Neural Pathways, Neurites, Animals, Pseudopodia, Cell-Movement, Microfilaments, Microfilament-Proteins, Cells, Cultured, Neural-Pathways, Body Patterning, Cerebral Cortex, Mice, Knockout, Body-Patterning, Mice, Inbred BALB C, Chimera, Growth-Cones, Mice-Inbred-C57BL, Microfilament Proteins, Cell Differentiation, Mice-Knockout, Phosphoproteins, Mice, Inbred C57BL, Actin Cytoskeleton, Nervous-System-Malformations, Cells-Cultured, Mutation, Female, Cell-Adhesion-Molecules, Cell Adhesion Molecules
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