A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
Copyright policy )A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
- Shanghai Jiao Tong University China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
- Soochow University China (People's Republic of)
- Huazhong University of Science and Technology China (People's Republic of)
- State Key Laboratory of Molecular Oncology China (People's Republic of)
Adult, Male, Nerve Tissue Proteins, AMP-Activated Protein Kinases, Middle Aged, Polymorphism, Single Nucleotide, Genetic Loci, Stomach Neoplasms, Case-Control Studies, Odds Ratio, Chromosomes, Human, Pair 5, Humans, Female, Chromosomes, Human, Pair 3, Receptors, Prostaglandin E, EP4 Subtype, Aged, Genome-Wide Association Study, Transcription Factors
Adult, Male, Nerve Tissue Proteins, AMP-Activated Protein Kinases, Middle Aged, Polymorphism, Single Nucleotide, Genetic Loci, Stomach Neoplasms, Case-Control Studies, Odds Ratio, Chromosomes, Human, Pair 5, Humans, Female, Chromosomes, Human, Pair 3, Receptors, Prostaglandin E, EP4 Subtype, Aged, Genome-Wide Association Study, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).249 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!