DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
Copyright policy )DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
Signaling from the DAF-2/insulin receptor to the DAF-16/FOXO transcription factor controls longevity, metabolism, and development in disparate phyla. To identify genes that mediate the conserved biological outputs of daf-2 /insulin-like signaling, we usedcomparative genomics to identify 17 orthologous genes from Caenorhabditis and Drosophila , each of which bears a DAF-16 binding site in the promoter region. One-third of these DAF-16 downstream candidate genes were regulatedby daf-2 /insulin-like signaling in C. elegans , and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, anddevelopment.
- Massachusetts Institute of Technology United States
- Massachusetts General Hospital United States
- Harvard University United States
Binding Sites, Gene Expression Profiling, Longevity, Computational Biology, Down-Regulation, Forkhead Transcription Factors, Genes, Insect, Genomics, Gene Expression Regulation, Mutation, Caenorhabditis, Animals, Insulin, Drosophila, RNA Interference, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Promoter Regions, Genetic, Conserved Sequence, Genes, Helminth
Binding Sites, Gene Expression Profiling, Longevity, Computational Biology, Down-Regulation, Forkhead Transcription Factors, Genes, Insect, Genomics, Gene Expression Regulation, Mutation, Caenorhabditis, Animals, Insulin, Drosophila, RNA Interference, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Promoter Regions, Genetic, Conserved Sequence, Genes, Helminth
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