Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population
Copyright policy )Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.All patients came from the east China area and underwent coronary angiography. Rs7025486 and rs1333049 polymorphism were genotyped in 555 patients with CAD and in 480 healthy controls that underwent coronary angiography.In Chinese population, the rs7025486 genotype in the case group was no significant different than the control group (P = 0.531).Meanwhile, the rs1333049 SNP has statistically significant (P = 0.006), which was the independent risk factors for CAD (OR1.252, P = 0.039), and consistent with the past studies conclusion.Genotype of rs1333049 on chromosome 9p21, but not rs7025486 on chromosome 9q33, is an independent determinant of the incidence of CAD in Chinese population.
- Shanghai Tenth People's Hospital China (People's Republic of)
- Tongji University China (People's Republic of)
- Tongji University School of Medicine China (People's Republic of)
- University of Nottingham Ningbo China China (People's Republic of)
Male, China, Genotype, Coronary Artery Disease, Middle Aged, Coronary artery disease, Single-nucleotide polymorphisms, Polymorphism, Single Nucleotide, rs702548, Asian People, RC666-701, Population Surveillance, Diseases of the circulatory (Cardiovascular) system, Humans, Female, Genetic Predisposition to Disease, rs1333049, Chromosomes, Human, Pair 9, Research Article, Aged
Male, China, Genotype, Coronary Artery Disease, Middle Aged, Coronary artery disease, Single-nucleotide polymorphisms, Polymorphism, Single Nucleotide, rs702548, Asian People, RC666-701, Population Surveillance, Diseases of the circulatory (Cardiovascular) system, Humans, Female, Genetic Predisposition to Disease, rs1333049, Chromosomes, Human, Pair 9, Research Article, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!