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https://dx.doi.org/10.1002/ani...
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The Crystal Structure of Human α2‐Macroglobulin Reveals a Unique Molecular Cage

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 31 Jan 2012 English Publisher:WileyJournal:Angewandte Chemie International Edition, volume 51, pages 3,340-3,344 (issn: 1433-7851, eissn: 1521-3773, Copyright policy )Funded by:EC | GUMS AND JOINTS
Authors: Marrero, Aniebrys; Duquerroy, Stephane; Trapani, Stefano; Goulas, Theodoros; Guevara, Tibisay; Andersen, Gregers Rom; Navaza, Jorge; +2 Authors

doi: 10.1002/anie.201108015 , 10.1002/ange.201108015

pmid: 22290936

The Crystal Structure of Human α2‐Macroglobulin Reveals a Unique Molecular Cage

Abstract

I'm your Venus: the crystal structure of the human methylamine-induced form of α(2)-macroglobulin (α(2)M) shows its large central cavity can accommodate two medium-sized proteinases. Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2)M.

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Keywords

Methylamines, Humans, Protease Inhibitors, alpha-Macroglobulins, Protein Multimerization, Crystallography, X-Ray, Protein Structure, Quaternary, Protein Structure, Tertiary

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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