Patchy fur,a Mouse Coat Mutation Associated with X–Y Nondisjunction, Maps to the Pseudoautosomal Boundary Region
Copyright policy )Patchy fur,a Mouse Coat Mutation Associated with X–Y Nondisjunction, Maps to the Pseudoautosomal Boundary Region
Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing.
- University of Southern California United States
- Institute of Cancer Research United Kingdom
- University of California System United States
- Jackson Laboratory United States
Genetic Markers, Male, Polymorphism, Genetic, X Chromosome, 610, Chromosome Mapping, 600, Mice, Inbred Strains, Mice, Mutant Strains, Contig Mapping, Mice, Mutation, Animals, Female, Chromosomes, Artificial, Yeast, Crosses, Genetic, DNA Primers, Hair
Genetic Markers, Male, Polymorphism, Genetic, X Chromosome, 610, Chromosome Mapping, 600, Mice, Inbred Strains, Mice, Mutant Strains, Contig Mapping, Mice, Mutation, Animals, Female, Chromosomes, Artificial, Yeast, Crosses, Genetic, DNA Primers, Hair
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