Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: A study from the colon cancer family registry
Copyright policy )Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: A study from the colon cancer family registry
In a previous study, alpha-1-antitrypsin (A1AT) deficiency alleles were found to be over represented among individuals with microsatellite unstable (MSI-high) colorectal cancers, and this was most significant in former or current smokers. We evaluated this association in a larger case-control study, stratified by microsatellite instability phenotypes. Concordant with prior observations, gender (female) and smoking history were positively associated with colorectal cancers having an MSI-high phenotype. No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype.
- University of Hawaii System United States
- National Oceanic and Atmospheric Administration United States
- Mayo Clinic United States
- National Institute of Health Pakistan
- Dartmouth College United States
Adult, Male, Smoking, Middle Aged, DNA Mismatch Repair, Immunohistochemistry, Risk Factors, Case-Control Studies, alpha 1-Antitrypsin Deficiency, Colonic Neoplasms, Odds Ratio, Humans, Family, Female, Registries
Adult, Male, Smoking, Middle Aged, DNA Mismatch Repair, Immunohistochemistry, Risk Factors, Case-Control Studies, alpha 1-Antitrypsin Deficiency, Colonic Neoplasms, Odds Ratio, Humans, Family, Female, Registries
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