Polarized localization of voltage-gated Na + channels is regulated by concerted FGF13 and FGF14 action
Copyright policy )Polarized localization of voltage-gated Na + channels is regulated by concerted FGF13 and FGF14 action
Significance Neurons concentrate voltage-gated sodium channels (VGSCs) in axons while limiting VGSCs in the somatodendritic compartment. This axonal concentration is important for efficient generation of the action potential, but it remains unclear what limits the concentration of VGSCs in the somatodendritic compartment. Here, we report that two highly similar molecules, FGF13 and FGF14, collaborate to maintain proper VGSC localization. FGF13 is a critical mediator of the process that keeps VGSCs low in the somatodendritic compartment, whereas FGF14 is an important regulator of VGSC localization to the axon.
- Duke University United States
- Duke University Health System United States
- Duke University Hospital United States
- Duke Medical Center United States
Neurons, Sodium, Action Potentials, Humans, Voltage-Gated Sodium Channels, Axons, Sodium Channels
Neurons, Sodium, Action Potentials, Humans, Voltage-Gated Sodium Channels, Axons, Sodium Channels
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