Paroxysmal nocturnal hemoglobinuria: Significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population
Copyright policy )Paroxysmal nocturnal hemoglobinuria: Significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the expansion of a PIG-A mutated hematopoietic stem cell. An immune-mediated origin has been suggested for this disease. Because HLA genes represent a susceptibility factor for autoimmunity, we investigated HLA genotype in 42 Italian PNH patients compared with 301 control subjects of the same ethnic origin. A significantly increased frequency of the HLA class I alleles A*0201 (p < 0.05), B*1402 (p < 0.001), and Cw*0802 (p < 0.005), and of the HLA class II DRB1*1501 (p < 0.01) with the linked DQB1*0602 (p
Adult, Male, APLASTIC-ANEMIA, PATHOGENESIS, Hemoglobinuria, Paroxysmal, HLA-C Antigens, TUBERCULOSIS, PHENOTYPE, FREQUENCY, DISEASE, Gene Frequency, HLA-DQ Antigens, Humans, HUMAN-LEUKOCYTE ANTIGEN; APLASTIC-ANEMIA; JAPANESE PATIENTS; T-CELLS; DISEASE; TUBERCULOSIS; PATHOGENESIS; PHENOTYPE; FREQUENCY; MHC, Alleles, Aged, HLA-A Antigens, JAPANESE PATIENTS, HUMAN-LEUKOCYTE ANTIGEN, HLA-DR Antigens, Middle Aged, Haplotypes, Italy, HLA-B Antigens, T-CELLS, Female, MHC
Adult, Male, APLASTIC-ANEMIA, PATHOGENESIS, Hemoglobinuria, Paroxysmal, HLA-C Antigens, TUBERCULOSIS, PHENOTYPE, FREQUENCY, DISEASE, Gene Frequency, HLA-DQ Antigens, Humans, HUMAN-LEUKOCYTE ANTIGEN; APLASTIC-ANEMIA; JAPANESE PATIENTS; T-CELLS; DISEASE; TUBERCULOSIS; PATHOGENESIS; PHENOTYPE; FREQUENCY; MHC, Alleles, Aged, HLA-A Antigens, JAPANESE PATIENTS, HUMAN-LEUKOCYTE ANTIGEN, HLA-DR Antigens, Middle Aged, Haplotypes, Italy, HLA-B Antigens, T-CELLS, Female, MHC
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