Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis
Copyright policy )Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis
Autoimmune diseases show complex pathological manifestations, which frequently involve systemic vasculitis. This complication is understood to be a manifestation of advanced disease, or to represent distinct entities, restricted by genetic and/or environmental factors. An MRL/Mp strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis coincidentally with glomerulonephritis, arthritis and sialoadenitis, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. Thus, this is a suitable model for analyzing the genetic basis of vasculitis in autoimmune diseases. To genetically dissect these complex pathological manifestations, a linkage analysis of each lesion with polymorphic microsatellite markers was performed by using MRL/lpr x (MRL/lpr x C3H/lpr)F1 backcross mice. Vasculitis-susceptible gene loci were mapped on chromosomes 3 and 4, which were not associated with glomerulonephritis, arthritis and sialoadenitis. These results indicate that systemic vasculitis in MRL/lpr mice may be under the control of host genes which are different from those for other autoimmune diseases.
- Kyoto University Japan
- Tohoku University Japan
- Ehime University Japan
- Hamamatsu University School of Medicine Japan
Genetic Markers, Vasculitis, Mice, Inbred C3H, Mice, Inbred MRL lpr, Arthritis, Apoptosis, Linkage Disequilibrium, Sialadenitis, Autoimmune Diseases, Disease Models, Animal, Mice, Glomerulonephritis, Antibodies, Antinuclear, Animals, Genetic Predisposition to Disease, fas Receptor, Gene Deletion, Microsatellite Repeats
Genetic Markers, Vasculitis, Mice, Inbred C3H, Mice, Inbred MRL lpr, Arthritis, Apoptosis, Linkage Disequilibrium, Sialadenitis, Autoimmune Diseases, Disease Models, Animal, Mice, Glomerulonephritis, Antibodies, Antinuclear, Animals, Genetic Predisposition to Disease, fas Receptor, Gene Deletion, Microsatellite Repeats
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