Background: Left main coronary disease (LMD) carries poorer prognosis and was observed to be heritable. Adiponectin gene encodes cytokine that attenuates inflammation on the vascular wall and was observed to be low in CAD. Single nucleotide polymorphisms (SNPs), SNP45-G and SNP276-T allele, have been associated to low levels of this protective cytokine. Our aim is to describe the prevalence of these SNPs in left main coronary artery (LMCA) involvement. Methods: Two hundred and thirteen volunteers from the Biobank with 45 having >10% LMCA stenosis (+LMS) group and 168 = 0.03) in the 51 60 year old group (38%). HTN (93.3%), dyslipidemia (80%), and Family History of CAD (51%) were prevalent but was not significant. Former smoking (57.8%) in this group were significantly prevalent. Severe 2 and 3 vessel disease (24%, 27%; 0.005) was also significantly common. Carriers of the G allele of SNP45 (62%; = 0.1) and T allele of SNP276 (58%; = 0.8) was prevalent in the +LMS group but was not statistically significant. Conclusion: Male Gender, HTN, dyslipidemia, former smoking and family history of CAD remains to be a risk factor of LMD. Severe multivessel CAD is associated to Left main involvement. SNPs of the adiponectin gene associated to low levels of adiponectin was seen more among those with Left main involvement.